(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate
Ropivacaine hydrochloride hydrate
CAS: 132112-35-7
Molecular Formula: C17H26N2O.ClH.H2O
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate - Names and Identifiers
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate - Physico-chemical Properties
| Molecular Formula | C17H26N2O.ClH.H2O |
| Molar Mass | 328.88 |
| Melting Point | 267-269°C |
| Boling Point | 495.9°C at 760 mmHg |
| Specific Rotation(α) | D20 -7.28° (c = 2 in water) |
| Flash Point | 253.7°C |
| Solubility | H2O: soluble5mg/mL, clear |
| Vapor Presure | 1.18E-10mmHg at 25°C |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | 2-8°C |
| In vitro study | Rpivacaine HCl is a local anesthetic. Rpivacaine HCl induces nerve block by reversibly inhibiting sodium ion flow in nerve fibers. The pKa of Ropivacaine HCl is ~ 8.2. Rpivacaine HCl has the potential to induce cardiovascular toxicity and CNS toxicity at high plasma concentrations. |
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate - Risk and Safety
| Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R41 - Risk of serious damage to eyes |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933399090 |
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate - Reference Information
| Overview | ropivacaine hydrochloride is an amide long-acting local anesthetic. Its fat-soluble than lidocaine, less than bupivacaine, the intensity of anesthesia for procaine 8 times. Because the products of its metabolism in the liver also have local anesthetic effect, the effect is more lasting. Mainly used for regional block anesthesia and epidural anesthesia, for postoperative and labor analgesia. |
| Use | ropivacaine hydrochloride is suitable for surgical anesthesia -epidural anesthesia, including cesarean section -- subarachnoid anesthesia -- regional block Acute Pain Control -- continuous epidural infusion or intermittent single medication, if postoperative or vaginal labor analgesia -regional block |
| biological activity | Ropivacaine HCl (LEA-103) is an anesthetic, block Impulse of the conduction on the nerve fibers by reversibly inhibiting the influx of sodium ions. |
| Target | IC50: sodium ion influenza IC50: 402.7 μm (TREK-1 in COS-7 cell's membrane) |
| Animal Model: | Adult Sprague-Dawley rats (300–400g) |
| Dosage: | 1 μM |
| Administration: | Infusion (added to the perfusate reservoir) |
| Result: | Attenuated pressure-dependent increases in filtration coefficient (K f ). |
Last Update：2024-04-09 21:21:28
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Multiple SpecificationsSpot supply
Product Name: Ropivacaine Hydrochloride Monohydrate CRS Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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